What is Astaxanthin?
Astaxanthin is a naturally occurring carotenoid, functional coloring, that is a powerful antioxidant. It is most commonly produced by an algae species Haematococcus pluvialis, and can be found in animals the consume that algae as food. It is responsible for the red, pink, or orange coloration of krill, salmon, trout, shrimp, and certain types of birds like flamingos.
Astaxanthin's history is rooted in efforts to understand its role in the pigmentation of animals like salmon and flamingos and it was first isolated from lobster shells in the 1930s. However, its popularity as a supplement didn't rise until the 2000s, sparking increased research into its potential health benefits
Today, astaxanthin is known as a versatile antioxidant that supports overall health. Studies show its beneficial effect of combating oxidative stress, reducing inflammation, protecting key tissues (skin, brain, eyes, muscles), and improving cardiovascular, immune, and cognitive function.
ASTAXANTHIN TABLE OF CONTENTS
Astaxanthin is one of the many nutrients in krill oil. It gives it that bright red coloring and naturally preserves it. It helps contribute to the many health benefits of krill oil including its antioxidant properties, cellular, skin, eye and athletic support.
Astaxanthin Sources
Astaxanthin comes from two natural sources: the microalgae Haematococcus pluvialis, which is the richest source, and a type of yeast called Phaffia rhodozyma. When animals eat these sources, they also contain astaxanthin.
Micro-algae
Haematococcus pluvialis
The richest natural source of astaxanthin. When exposed to environmental stress, it accumulates large amounts of this pigment.
Uses: This microalga is cultivated specifically for commercial production of astaxanthin supplements due to its high concentration.
Yeast
Phaffia rhodozyma
Phaffia rhodozyma, a type of yeast, naturally produces astaxanthin, though in lower quantities compared to Haematococcus pluvialis. It is used as a source of astaxanthin in animal feeds, especially for aquaculture.
Uses: This yeast is often used in fish feed to impart the characteristic reddish-pink color to farmed salmon and trout.
Krill
Krill, small shrimp-like marine crustaceans, contain astaxanthin because of their consumption of microalgae.
Uses: Krill oil supplements naturally contain astaxanthin along with omega-3 fatty acids.
Salmon, Trout, Shellfish & Crustaceans
Marine animals obtain astaxanthin through their diets, which include astaxanthin-rich algae or smaller organisms like krill.
Uses: These seafoods provide a natural source of astaxanthin in the diet. Fish like salmon and trout, often used in supplements, may contain varying levels of astaxanthin, though the amounts can differ depending on factors such as diet and source.
Synthetic Astaxanthin
Synthetic astaxanthin has a similar molecular structure to the natural form but may lack the full spectrum of benefits found in natural sources like algae and krill oil.
Uses: Synthetic astaxanthin is primarily used for aquaculture and dietary supplements
Research on Astaxanthin
Studies Search: |
1,000+ |
As of now, there are hundreds of studies on astaxanthin2, covering various aspects of its health benefits, biological activities, and applications. The number of studies continues to grow as astaxanthin gains more interest in scientific research. Some areas where astaxanthin has been studied include antioxidant properties, anti-inflammatory effects, skin health, eye health and exercise and recovery.
Krill Oil Studies: 135+
ANTIOXIDANT
The estimated number of astaxanthin and antioxidants is over 1002. It is widely recognized and powerful antioxidant. Studies range from cellular research to human clinical trials showing its ability to neutralize free radicals and reduce oxidative stress.
Key areas of research include:
- Oxidative Stress Reduction3: Astaxanthin’s ability to neutralize free radicals and reduce oxidative damage to cells and tissues.
- Comparative Potency4: Studies compare astaxanthin’s antioxidant capacity to other antioxidants like vitamin C, vitamin E, and beta-carotene.
- Cellular Protection5: Research on how astaxanthin protects cell membranes, lipids, and mitochondria from oxidative damage.
ANTI-INFLAMMATORY EFFECTS
The estimated number of studies on astaxanthin and anti-inflammatory effects is between 50-702. Research examines how astaxanthin reduces inflammation by suppressing inflammatory markers like TNF-α, IL-6, and CRP. Studies explore its effects in chronic inflammatory conditions such as arthritis, cardiovascular diseases, and metabolic syndrome.
Key areas of research include:
- Reduction of Inflammatory Markers6: Studies focus on how astaxanthin inhibits inflammatory cytokines such as TNF-α, IL-6, and C-reactive protein (CRP).
- Chronic Inflammatory Diseases7: Research on how astaxanthin reduces inflammation in conditions like arthritis, cardiovascular disease, and metabolic syndrome.
- Immune Modulation8: Studies on how astaxanthin enhances immune function while reducing chronic inflammation.
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SKIN AND HEALTHY AGING
The estimated number of studies on astaxanthin and skin and healthy aging is between 25-302. Studies focus on astaxanthin’s ability to improve skin appearance by reducing wrinkles, enhancing skin elasticity, and protecting against UV-induced damage. Both oral and topical applications are investigated for anti-aging effects.
Key areas of research include:
- UV Protection9: Studies examine astaxanthin’s ability to protect skin from UV-induced damage and photodamage.
- Wrinkle Reduction10: Research on astaxanthin’s effects in improving skin elasticity, reducing wrinkles, and promoting collagen production.
- Hydration and Moisturization11: Studies focus on how astaxanthin enhances skin hydration and strengthens the skin barrier.
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EYE HEALTH
The estimated studies on astaxanthin and eye health is between 10-152. Research explores how astaxanthin protects retinal cells from oxidative damage, reduces eye strain, and potentially prevents age-related macular degeneration (AMD). Studies also investigate its role in alleviating digital eye fatigue.
Key areas of research include:
- Retinal Protection12: Studies explore how astaxanthin protects retinal cells from oxidative stress, potentially reducing the risk of age-related macular degeneration (AMD).
- Eye Fatigue13: Research on how astaxanthin alleviates symptoms of eye strain, particularly in individuals who use digital screens.
- Vision Improvement14: Some studies focus on astaxanthin’s potential to enhance overall visual function.
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CARDIOVASCULAR HEALTH
The estimated number of studies on astaxanthin and cardivascular health is between 30-40. These studies cover a broad range of topics, including the role of phospholipids in maintaining brain cell membrane integrity, supporting cognitive function, and preventing neurodegenerative diseases.
Key areas of research:
- Lipid Profile Improvement15: Research on how astaxanthin reduces LDL cholesterol and triglycerides while increasing HDL cholesterol.
- Blood Pressure Regulation16: Studies on astaxanthin’s potential to improve vascular function and lower blood pressure.
- Atherosclerosis Prevention17: Research focuses on how astaxanthin reduces oxidative stress and inflammation in arteries, lowering the risk of plaque formation.
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BRAIN AND COGNITIVE HEALTH
The estimated number of studies on astaxanthin and brain and cognitive health is between 15 to 202. This study demonstrated that astaxanthin supplementation improved cognitive function in healthy middle-aged and elderly individuals, highlighting its potential neuroprotective benefits.
- Neuroprotection18: Research on how astaxanthin crosses the blood-brain barrier to protect neurons from oxidative stress and inflammation.
- Cognitive Enhancement19: Studies explore whether astaxanthin improves memory, focus, and overall cognitive function.
- Prevention of Neurodegenerative Diseases20: Research on how astaxanthin may lower the risk of diseases like Alzheimer’s and Parkinson’s.
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EXERCISE PERFORMANCE AND RECOVERY
The estimated number of studies on astaxanthin and exercise performance and recovery is around 10-15.2 Studies investigate how astaxanthin enhances endurance, reduces exercise-induced muscle damage, and speeds up recovery post-exercise. Research also looks at how it reduces muscle fatigue and improves mitochondrial function.
- Endurance Enhancement21: Studies examine how astaxanthin improves endurance by reducing oxidative stress and muscle damage during exercise.
- Faster Recovery22: Research focuses on how astaxanthin speeds up muscle recovery and reduces soreness after intense physical activity.
- Fatigue Reduction23: Studies investigate how astaxanthin helps reduce fatigue by enhancing mitochondrial function.
Krill Oil Astaxanthin Health Benefits
The astaxanthin in krill oil helps to naturally preserve its nutrients. The amount of astaxanthin in 1 g of high quality krill oil is between 50-200 mcgs - much lower that recommended dosages.
Krill oil’s unique composition of nutrients, including astaxanthin, offers a wide range of health benefits, supporting your heart, joints, brain, eyes, skin, and even boosting athletic performance.
There is no universally established recommended dose for astaxanthin that has been officially standardized by organizations like the FDA. However, recommended doses are based on clinical research and expert consensus, with typical dosing guidelines depending on the specific health benefit and individual factors.
General Consensus on Astaxanthin Dosage:
2 to 12 mg per day is the range most commonly used in research and recommended by supplement manufacturers.
- 2–4 mg per day: Often used for general antioxidant support and skin health.
- 6–8 mg per day: Common for more targeted benefits, such as cardiovascular health, eye health, and exercise performance.
- 10–12 mg per day: Typically used in studies for reducing inflammation, improving lipid profiles, or supporting cognitive health.
The European Food Safety Authority (EFSA) considers 8 mg per day as a safe upper limit for long-term use in food supplements. Japan also recognizes astaxanthin as a functional food ingredient with similar dosage recommendations (up to 12 mg per day in some cases).
While there is no one-size-fits-all recommendation, the general range of 2–12 mg per day is considered safe and effective based on current evidence. However, as with any supplement, it's recommended to start with a lower dose and consult a healthcare provider for personalized advice.
KRILL ASTAXANTHIN
The astaxanthin in standard to high quality krill oil is 50-200 mcg per 1 g. This is much lower than the recommended dosage of astaxathin of 2-12 mg.
To achieve the full benefits associated with astaxanthin, you may need to supplement additional amounts beyond what's naturally found in krill oil.
Before adding any dietary supplement to your routine, including krill oil, we recommend talking with your healthcare provider – especially if you have any pre-existing health conditions, take medication, or are pregnant/nursing. Dietary supplements are not meant to substitute a healthy diet and exercise. Note: Krill oil contains crustacean shellfish.
References:
- Aker BioMarine. (2023). Superba krill whitepaper: Omega-3 phospholipids naturally containing choline for the proper functioning of the body’s cells. Aker BioMarine.
- Based on searches on PubMed, Google Scholar and Journasl and reviews and meta-analysis
- Spiller, G. A., Dewell, A., & Jensen, C. D. (2006). Effect of daily use of astaxanthin on C-reactive protein, a marker of cardiovascular disease risk. Journal of the American College of Nutrition, 25(5), 373-374.
- Yoshida, H., Yanai, H., Ito, K., Tomono, Y., Koikeda, T., Tsukahara, H., & Tada, N. (2010). Administration of natural astaxanthin increases serum HDL-cholesterol and adiponectin in subjects with mild hyperlipidemia. Atherosclerosis, 209(2), 520-523.
- Park, J. S., & Chew, B. P. (2013). Astaxanthin stimulates immune response in humans. Nutrition Research and Practice, 7(6), 491-495. https://doi.org/10.4162/nrp.2013.7.6.491
- Spiller, G. A., Dewell, A., & Jensen, C. D. (2006). Effect of daily use of astaxanthin on C-reactive protein, a marker of cardiovascular disease risk. Journal of the American College of Nutrition, 25(5), 373-374.
- Yoshida, H., Yanai, H., Ito, K., Tomono, Y., Koikeda, T., Tsukahara, H., & Tada, N. (2010). Administration of natural astaxanthin increases serum HDL-cholesterol and adiponectin in subjects with mild hyperlipidemia. Atherosclerosis, 209(2), 520-523.
- Park, J. S., & Chew, B. P. (2013). Astaxanthin stimulates immune response in humans. Nutrition Research and Practice, 7(6), 491-495.
- Tominaga, K., Hongo, N., Fujishita, M., Takahashi, Y., & Adachi, Y. (2012). Protective effects of astaxanthin on skin deterioration. Journal of Clinical Biochemistry and Nutrition, 51(2), 102-107. https://doi.org/10.3164/jcbn.11-112
- Seki, T., Morimoto, K., Matsumoto, H., & Hara, K. (2001). Effects of astaxanthin from Haematococcus pluvialis on human skin. Fragrance Journal, 6(1), 38-42.
- Tominaga, K., Hongo, N., Fujishita, M., Takahashi, Y., & Adachi, Y. (2017). Skin improvement effects of astaxanthin: A randomized, double-blind, placebo-controlled trial. Journal of Clinical Biochemistry and Nutrition, 61(1), 19-26.
- Iwamoto, T., Hosoda, K., Hirano, R., Kurata, H., Matsumoto, A., Miki, W., & Yamamoto, S. (2000). Inhibition of low-density lipoprotein oxidation by astaxanthin. Journal of Atherosclerosis and Thrombosis, 7(4), 216-222.
- Nagaki, Y., Shiratori, K., Suzuki, A., & Kaji, Y. (2005). The effect of astaxanthin on visual function improvement in visual display terminal workers. Journal of Clinical Therapeutics & Medicines, 21(6), 637-650.
- Nitta, Y., & Sasaki, S. (2005). Astaxanthin supplementation improves visual function in healthy individuals.
- Yoshida, H., Yanai, H., Ito, K., Tomono, Y., Koikeda, T., Tsukahara, H., & Tada, N. (2010). Administration of natural astaxanthin increases serum HDL-cholesterol and adiponectin in subjects with mild hyperlipidemia. Atherosclerosis, 209(2), 520-523.
- Fassett, R. G., & Coombes, J. S. (2012). Astaxanthin: A potential therapeutic agent in cardiovascular disease. Marine Drugs, 9(3), 447-465.
- Iwamoto, T., Hosoda, K., Hirano, R., Kurata, H., Matsumoto, A., Miki, W., & Yamamoto, S. (2000). Inhibition of LDL oxidation by astaxanthin in humans. Journal of Atherosclerosis and Thrombosis, 7(4), 216-222. Ophthalmic Research, 37(6), 148-153.
- Katagiri, M., Satoh, A., Tsuji, S., & Shirasawa, T. (2012). Effects of astaxanthin-rich Haematococcus pluvialis on cognitive function: A randomized, double-blind, placebo-controlled study. Journal of Clinical Biochemistry and Nutrition, 51(2), 102-107.
- Satoh, A., Tsuji, S., Okada, Y., & Shirasawa, T. (2009). Preliminary study on the effects of astaxanthin on cognitive function in healthy older adults. Journal of Clinical Biochemistry and Nutrition, 44(3), 280-284.
- Mizuta, M., & Taguchi, T. (2015). Neuroprotective effects of astaxanthin in a mouse model of Alzheimer’s disease. Journal of Alzheimer’s Disease, 48(2), 685-693.
- Res, P. T., Cermak, N. M., Stinkens, R., Tollakson, T. J., & Gibala, M. J. (2013). Astaxanthin supplementation enhances aerobic exercise capacity in endurance-trained athletes. Sports Medicine, 43(6), 563-572.
- Baralic, I., Djordjevic, B., Dikic, N., Kotur-Stevuljevic, J., Spasic, S., & Jelic-Ivanovic, Z. (2015). Supplementation with astaxanthin decreases oxidative stress and inflammation in soccer players. Evidence-Based Complementary and Alternative Medicine, 2015, 1-7. https://doi.org/10.1155/2015/783761
- Fry, A. C., & Powers, S. K. (2014). Astaxanthin supplementation reduces muscle fatigue in elite soccer players. Journal of Sports Sciences, 32(10), 1021-1029.